Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2

Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.

T helper 17 (Th17) cells specifically transcribe the Il17 and Il17f genes, which are localized in the same chromosome region, but the underlying mechanism is unclear. Here, we report a cis element that we previously named conserved noncoding sequence 2 (CNS2) physically interacted with both Il17 and Il17f gene promoters and was sufficient for regulating their selective transcription in Th17 cel...

Cellular Senescence in Yeast Is Regulated by rDNA Noncoding Transcription

Genomic instability is a conserved factor in lifespan reduction, although the molecular mechanism is not known. Studies in the yeast Saccharomyces cerevisiae over the past 20 years have found a connection between the ribosomal RNA gene cluster (rDNA) and lifespan. The highly repetitive rDNA exhibits genomic instability, and the antiaging histone deacetylase gene SIR2 regulates this instability....

Conserved Noncoding Sequence 1 Naive T Cells by the + Maturation of CD 4 Regulation of DNA

Evolutionarily Conserved Noncoding DNA

After decades of ignominy as ‘junk’, ‘parasite’ or ‘selfish’, noncoding deoxyribonucleic acid (DNA) present in introns and intergenic regions has recently been recognized as symbolizing a rich fossil record of DNA sequences subject to variation and conservation throughout evolution. In addition to clusters of evolutionarily conserved genes in close proximity to one another, human chromosomes al...

A transcription switch toggled by noncoding RNAs.

L ife is really getting complicated in the world of eukaryotic transcription. In the good old days, we were comfortable in the belief that transcription occurred primarily across the coding region of a gene, producing an mRNA for translation. However, over the past few years, this view has been turned topsy-turvy. Improved microarray and sequencing technologies have revealed that our picture of...